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IONS

HEALTHY

IONIS PHARMACEUTICALS INC

CIK: 0000874015

Strong Sell (90% confidence)

Last activity: Yesterday

Financial Metrics

As of Dec 31, 2024 (10-K)

Revenue $226.58M
Net Income -$88.28M
Total Cash $2.30B
Total Debt $539.11M
Debt/Equity 0.92

Insider Roster (15 total, 15 active)

Insider Buys Sells Net Value Holdings
Monia Brett P
Chief Executive Officer
 		0 3 -$11.03M
254,497 shares
$21.83M
BENNETT C FRANK
EVP, Chief Scientific Officer
 		0 5 -$8.22M
80,293 shares
$6.67M
Devers Shannon L.
EVP, Chief Human Resources Ofc
 		0 8 -$6.08M
22,541 shares
$1.83M
Swayze Eric
EVP Research
 		0 7 -$4.40M
38,312 shares
$3.12M
HERMAN JOAN E
DIRECTOR
 		0 2 -$3.17M
46,086 shares
$3.32M
WENDER JOSEPH H
DIRECTOR
 		0 2 -$2.26M
43,464 shares
$3.51M
HOUGEN ELIZABETH L
EVP, Finance & CFO
 		0 2 -$1.55M
132,881 shares
$11.06M
Schneider Eugene
EVP, Chf Clinical Develop Ofcr
 		0 2 -$1.22M
69,702 shares
$5.82M
O'NEIL PATRICK R.
EVP CLO & General Counsel
 		0 2 -$1.21M
71,983 shares
$6.01M
Birchler Brian
EVP, Corp and Development Ops
 		0 2 -$1.15M
66,247 shares
$5.50M
Baroldi Joseph
EVP, Chief Business Officer
 		0 3 -$1.05M
45,413 shares
$3.77M
KLEIN JOSEPH III
DIRECTOR
 		0 3 -$960K
Holdings: -
Value: -
PARSHALL B LYNNE
DIRECTOR
 		0 1 -$414K
56,344 shares
$4.66M
Kordasiewicz Holly B.
EVP, Chief Development Officer
 		0 1 -$313K
14,718 shares
$1.11M
Jenne Kyle
EVP, Chf GL Pdt Str Ofcr
 		0 1 -$138K
16,389 shares
$1.24M

Recent Transactions

SELL Swayze Eric (EVP Research)

9,435 shares @ $81.56

$770K

Feb 13, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

6,207 shares @ $82.07

$509K

Feb 13, 2026

Conviction: | View SEC Filing →
SELL PARSHALL B LYNNE (DIRECTOR)

5,000 shares @ $82.72

$414K

Feb 11, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

29,430 shares @ $85.79

$2.52M

Feb 6, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

48,626 shares @ $83.03

$4.04M

Feb 2, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

20,000 shares @ $82.60

$1.65M

Feb 2, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

16,463 shares @ $83.03

$1.37M

Feb 2, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

62,970 shares @ $82.72

$5.21M

Jan 30, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

6,988 shares @ $83.24

$582K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL O'NEIL PATRICK R. (EVP CLO & General Counsel)

6,179 shares @ $83.53

$516K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Schneider Eugene (EVP, Chf Clinical Develop Ofcr)

6,179 shares @ $83.45

$516K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Birchler Brian (EVP, Corp and Development Ops)

6,179 shares @ $83.03

$513K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

6,179 shares @ $82.93

$512K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

5,885 shares @ $82.95

$488K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

5,296 shares @ $82.96

$439K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

3,977 shares @ $81.34

$323K

Jan 22, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

44,034 shares @ $74.82

$3.29M

Jan 16, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

12,922 shares @ $75.22

$972K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

9,884 shares @ $75.34

$745K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Schneider Eugene (EVP, Chf Clinical Develop Ofcr)

9,302 shares @ $75.59

$703K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL O'NEIL PATRICK R. (EVP CLO & General Counsel)

9,191 shares @ $75.84

$697K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

8,977 shares @ $75.15

$675K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Birchler Brian (EVP, Corp and Development Ops)

8,480 shares @ $75.11

$637K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

8,353 shares @ $75.95

$634K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

6,907 shares @ $75.75

$523K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Kordasiewicz Holly B. (EVP, Chief Development Officer)

4,141 shares @ $75.66

$313K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Jenne Kyle (EVP, Chf GL Pdt Str Ofcr)

1,823 shares @ $75.96

$138K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

1,149 shares @ $75.78

$87K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

49 shares @ $75.97

$4K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

25,545 shares @ $85.36

$2.18M

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

9,264 shares @ $84.62

$784K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

3,829 shares @ $84.62

$324K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

3,460 shares @ $84.62

$293K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

2,101 shares @ $85.36

$179K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

18,338 shares @ $79.27

$1.45M

Jan 2, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

5,125 shares @ $78.57

$403K

Jan 2, 2026

Conviction: | View SEC Filing →
SELL WENDER JOSEPH H (DIRECTOR)

20,571 shares @ $80.67

$1.66M

Dec 1, 2025

Conviction: | View SEC Filing →
SELL WENDER JOSEPH H (DIRECTOR)

7,429 shares @ $81.23

$603K

Dec 1, 2025

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

16,777 shares @ $80.91

$1.36M

Nov 25, 2025

Conviction: | View SEC Filing →
SELL KLEIN JOSEPH III (DIRECTOR)

4,000 shares @ $80.00

$320K

Nov 25, 2025

Conviction: | View SEC Filing →
SELL KLEIN JOSEPH III (DIRECTOR)

4,000 shares @ $80.00

$320K

Nov 25, 2025

Conviction: | View SEC Filing →
SELL KLEIN JOSEPH III (DIRECTOR)

4,000 shares @ $80.00

$320K

Nov 25, 2025

Conviction: | View SEC Filing →
SELL HERMAN JOAN E (DIRECTOR)

32,000 shares @ $72.13

$2.31M

Nov 19, 2025

Conviction: | View SEC Filing →
SELL HERMAN JOAN E (DIRECTOR)

12,000 shares @ $72.13

$866K

Nov 19, 2025

Conviction: | View SEC Filing →

⚠️ Important Disclaimer

• This is AI-generated analysis for educational purposes only, not financial advice.

• Insider trading data is derived from SEC Form 4 filings and may contain errors.

• Always conduct your own research and consult qualified financial advisors before making investment decisions.