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IONS

HEALTHY

IONIS PHARMACEUTICALS INC

CIK: 0000874015

Strong Sell (90% confidence)

Last activity: 2 weeks ago

Financial Metrics

As of Dec 31, 2025 (10-K)

Revenue $372.78M
Net Income -$381.39M
Total Debt $1.76B
Debt/Equity 3.60
Current Ratio 3.83

Insider Roster (15 total, 15 active)

Insider Buys Sells Net Value Holdings
Monia Brett P
Chief Executive Officer
 		0 8 -$23.14M
242,662 shares
$18.52M
HOUGEN ELIZABETH L
EVP, Finance & CFO
 		0 5 -$17.87M
82,660 shares
$6.05M
BENNETT C FRANK
EVP, Chief Scientific Officer
 		0 8 -$14.96M
94,043 shares
$7.44M
Devers Shannon L.
EVP, Chief Human Resources Ofc
 		0 10 -$6.31M
28,326 shares
$2.24M
Swayze Eric
EVP Research
 		0 7 -$4.40M
38,312 shares
$3.12M
Diaz Allene M.
DIRECTOR
 		0 3 -$4.35M
19,424 shares
$1.54M
Jenne Kyle
EVP, Chf GL Pdt Str Ofcr
 		0 3 -$2.97M
27,800 shares
$2.10M
O'NEIL PATRICK R.
EVP CLO & General Counsel
 		0 3 -$1.98M
62,211 shares
$4.68M
KLEIN JOSEPH III
DIRECTOR
 		0 3 -$1.70M
18,820 shares
$1.49M
Schneider Eugene
EVP, Chf Clinical Develop Ofcr
 		0 3 -$1.63M
63,890 shares
$4.53M
Baroldi Joseph
EVP, Chief Business Officer
 		0 8 -$1.58M
4,347 shares
$348K
Birchler Brian
EVP, Corp and Development Ops
 		0 2 -$1.15M
66,247 shares
$5.50M
PARSHALL B LYNNE
DIRECTOR
 		0 1 -$414K
56,344 shares
$4.66M
Kordasiewicz Holly B.
EVP, Chief Development Officer
 		0 1 -$313K
14,718 shares
$1.11M
LOSCALZO JOSEPH
DIRECTOR
 		0 2 -$83K
36,330 shares
$2.91M

Recent Transactions

SELL Schneider Eugene (EVP, Chf Clinical Develop Ofcr)

5,812 shares @ $70.97

$412K

Mar 19, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

10,172 shares @ $73.21

$745K

Mar 17, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

205,608 shares @ $72.38

$14.88M

Mar 16, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

9,440 shares @ $72.77

$687K

Mar 16, 2026

Conviction: | View SEC Filing →
SELL Jenne Kyle (EVP, Chf GL Pdt Str Ofcr)

21,191 shares @ $75.50

$1.60M

Mar 10, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

17,591 shares @ $76.34

$1.34M

Mar 10, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

16,512 shares @ $75.47

$1.25M

Mar 10, 2026

Conviction: | View SEC Filing →
SELL Jenne Kyle (EVP, Chf GL Pdt Str Ofcr)

16,086 shares @ $76.30

$1.23M

Mar 10, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

117,604 shares @ $75.26

$8.85M

Mar 9, 2026

Conviction: | View SEC Filing →
SELL O'NEIL PATRICK R. (EVP CLO & General Counsel)

10,148 shares @ $75.25

$764K

Mar 9, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

7,382 shares @ $74.11

$547K

Mar 9, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

1,684 shares @ $75.58

$127K

Mar 9, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

238 shares @ $80.00

$19K

Mar 4, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

201 shares @ $80.00

$16K

Mar 4, 2026

Conviction: | View SEC Filing →
SELL LOSCALZO JOSEPH (DIRECTOR)

200 shares @ $80.00

$16K

Mar 4, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

71,600 shares @ $79.10

$5.66M

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Diaz Allene M. (DIRECTOR)

39,265 shares @ $79.11

$3.11M

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Diaz Allene M. (DIRECTOR)

14,608 shares @ $79.88

$1.17M

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

14,321 shares @ $79.11

$1.13M

Mar 3, 2026

Conviction: | View SEC Filing →
SELL KLEIN JOSEPH III (DIRECTOR)

13,526 shares @ $79.17

$1.07M

Mar 3, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

12,687 shares @ $79.88

$1.01M

Mar 3, 2026

Conviction: | View SEC Filing →
SELL KLEIN JOSEPH III (DIRECTOR)

6,794 shares @ $80.00

$543K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

5,030 shares @ $80.00

$402K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

4,096 shares @ $79.36

$325K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

2,088 shares @ $80.41

$168K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL KLEIN JOSEPH III (DIRECTOR)

1,012 shares @ $80.82

$82K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Diaz Allene M. (DIRECTOR)

1,005 shares @ $80.80

$81K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL LOSCALZO JOSEPH (DIRECTOR)

832 shares @ $80.33

$67K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

802 shares @ $80.76

$65K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

755 shares @ $80.84

$61K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

36 shares @ $81.01

$3K

Mar 3, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

9,435 shares @ $81.56

$770K

Feb 13, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

6,207 shares @ $82.07

$509K

Feb 13, 2026

Conviction: | View SEC Filing →
SELL PARSHALL B LYNNE (DIRECTOR)

5,000 shares @ $82.72

$414K

Feb 11, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

29,430 shares @ $85.79

$2.52M

Feb 6, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

48,626 shares @ $83.03

$4.04M

Feb 2, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

20,000 shares @ $82.60

$1.65M

Feb 2, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

16,463 shares @ $83.03

$1.37M

Feb 2, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

62,970 shares @ $82.72

$5.21M

Jan 30, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

6,988 shares @ $83.24

$582K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL O'NEIL PATRICK R. (EVP CLO & General Counsel)

6,179 shares @ $83.53

$516K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Schneider Eugene (EVP, Chf Clinical Develop Ofcr)

6,179 shares @ $83.45

$516K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Birchler Brian (EVP, Corp and Development Ops)

6,179 shares @ $83.03

$513K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

6,179 shares @ $82.93

$512K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

5,885 shares @ $82.95

$488K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

5,296 shares @ $82.96

$439K

Jan 30, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

3,977 shares @ $81.34

$323K

Jan 22, 2026

Conviction: | View SEC Filing →
SELL Monia Brett P (Chief Executive Officer)

44,034 shares @ $74.82

$3.29M

Jan 16, 2026

Conviction: | View SEC Filing →
SELL HOUGEN ELIZABETH L (EVP, Finance & CFO)

12,922 shares @ $75.22

$972K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

9,884 shares @ $75.34

$745K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Schneider Eugene (EVP, Chf Clinical Develop Ofcr)

9,302 shares @ $75.59

$703K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL O'NEIL PATRICK R. (EVP CLO & General Counsel)

9,191 shares @ $75.84

$697K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL BENNETT C FRANK (EVP, Chief Scientific Officer)

8,977 shares @ $75.15

$675K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Birchler Brian (EVP, Corp and Development Ops)

8,480 shares @ $75.11

$637K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

8,353 shares @ $75.95

$634K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

6,907 shares @ $75.75

$523K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Kordasiewicz Holly B. (EVP, Chief Development Officer)

4,141 shares @ $75.66

$313K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Jenne Kyle (EVP, Chf GL Pdt Str Ofcr)

1,823 shares @ $75.96

$138K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Baroldi Joseph (EVP, Chief Business Officer)

1,149 shares @ $75.78

$87K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

49 shares @ $75.97

$4K

Jan 16, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

25,545 shares @ $85.36

$2.18M

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

9,264 shares @ $84.62

$784K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

3,829 shares @ $84.62

$324K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

3,460 shares @ $84.62

$293K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Devers Shannon L. (EVP, Chief Human Resources Ofc)

2,101 shares @ $85.36

$179K

Jan 7, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

18,338 shares @ $79.27

$1.45M

Jan 2, 2026

Conviction: | View SEC Filing →
SELL Swayze Eric (EVP Research)

5,125 shares @ $78.57

$403K

Jan 2, 2026

Conviction: | View SEC Filing →

⚠️ Important Disclaimer

• This is AI-generated analysis for educational purposes only, not financial advice.

• Insider trading data is derived from SEC Form 4 filings and may contain errors.

• Always conduct your own research and consult qualified financial advisors before making investment decisions.